The boxer moved to a 50-0 career record as he proved too good for the upstart from the world of UFC.
McGregor's night began promisingly, with some impressive blows landed in the early round.
But as the fight grew on class was always going to tell, and Mayweather began to assert his dominance.
The referee called a halt to proceedings in the 10th round.
Here's our boxing correspondent Gareth A Davies's round-by-round verdict, with scores for each round from our panel of guest judges:
Round 1
Very smart round by McGregor, excellent attacks,
Round 2
Mayweather doing little apart from one body shot,
Round 3
McGregor's unorthodox movement from
Round 4
Weird so far from Mayweather. But he's opened up a bit more this round and although he's landing he's also getting caught. Good shot on McGregor'
Round 5
McG still working hard but May goes to his stomach again and then a right from the American. They tie up. McG is so much bigger. Left-right from M
Round 6
May really switched it up that round and was more aggressive than he is accustomed to be. McG finding it hard in there but enjoying the challenge
Round 7
Series of big right hands from Floyd who looks like he is seeking a finish now. He rocks McGregor's head back twice. May also lands good right. Mc
Round 8
Good round for Mystic Mac, he just landed more.
Round 9
Massive round and it could be close to the end unless McG rallies strongly. Good right from Floyd. And another. And another. McG holds. Legs a
Round 10
And it's over. Hard concussive, accurate punches rain in from Mayweather who is hurting McGregor who stumbles across the ring and into the ropes from a right hand, off balance, and is close to going down. The attack continues. Left. Right. Left. M
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